RAF Typhoon FGR4s have operated alongside French warplanes in a joint strike against an hidden munitions depot in Syrian territory operated by the IS group, per a report from the UK Ministry of Defence.
The location, pinpointed through intelligence, was believed to be housing weapons and explosive materials, the statement said, and was positioned in mountains just above the ancient city of Palmyra in central Syria.
"Our fighter planes utilized laser-guided Paveway IV weapons to target a number of entry passages providing entry to the facility... initial indications indicate the target was engaged successfully," officials stated.
There was no indication of any civilian impact in the attack on Saturday evening and every plane involved returned to base without incident, the ministry further stated.
The Typhoon FGR4s were backed up by a Voyager aerial refuelling aircraft.
IS - referred to as ISIS - imposed extremist governance over significant areas in both Syria and Iraq before its territorial defeat in 2019.
"This action demonstrates the UK's leading role, and commitment to stand shoulder to shoulder with our allies, to stamp out any resurgence of the terrorist group and their violent and radical beliefs in the Middle East," the British Defence Secretary the minister remarked.
UK warplanes have conducted overwatch operations over Syria to "deter any efforts to regroup" of the group after its routing at the battle of Baghuz in 2019, the MoD reported.
"I must thank the personnel of British forces involved in this operation for their expertise and their bravery," the Defence Secretary added. "They were part of numerous UK service members on duty over Christmas and New Year. This action, to remove terrorist threats who pose a risk to our safety, demonstrates how British military are ready to step up, throughout the year, ensuring Britain's security at home and powerful internationally."
Last December, the United States armed forces conducted what it termed a "massive strike" targeting IS targets in Syria, following an assault resulted in the deaths of two US troops and a civilian interpreter in the Palmyra area.
The United Nations estimates Islamic State still has roughly 5-7 thousand militants in both countries.